tagA [2018-05-30 13:27:40]

UDP-N-acetyl-D-mannosamine transferase

Locus: BSU35750

Isoelectric point: 10.13

Molecular weight: 29.35 kDa

Protein length: 256 aa

Gene length: 768 bp

Function: biosynthesis of teichoic acid

Product: UDP-N-acetyl-D-mannosamine transferase

Essential: yes

E.C.: 2.4.1.187

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of teichoic acid
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of teichoic acid
• Groups of genes → Essential genes

Gene

Coordinates: 3,681,370 → 3,682,140

Phenotypes of a mutant

• essential PubMed, reduced growth rate, loss of rod-like morphology PubMed
• inactivation of tagA strongly restores beta-lactam resistance in a sigM mutant PubMed

The protein

Catalyzed reaction/ biological activity

• UDP-N-acetyl-D-mannosamine N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol (according to Swiss-Prot)

Protein family

• glycosyltransferase 26 family (according to Swiss-Prot)

Localization

• secreted (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: tagA-tagB
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • PhoP: repression, PubMed, in PhoP regulon
  • WalR: activation, PubMed, in WalR regulon

  Regulation

  • repressed when phosphate is available (PhoP) PubMed
  • the leader mRNA is processed upstream of tagA by RNase Y, this requires the YmcA-YlbF-YaaT complex PubMed

References

Reviews

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Original publications

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